In Mail, I frequently want to go to the first or last message in my list. On windows, the home and end keys work well for this. On MacOS, they don’t work in NSTableView/NSOutlineView by default. However, alt-up arrow and alt-down arrow will go to the end/start of the table. But, in Mail, this behavior goes to the next/previous message in a series. BUT! if you hold down alt-up arrrow for a brief second, it will take you to the start of your messages (and, alt-down arrow to go to the end). cool..
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